{"id":12179,"date":"2025-08-08T11:00:00","date_gmt":"2025-08-08T11:00:00","guid":{"rendered":"https:\/\/filarabiomed.ro\/?post_type=product&p=12179"},"modified":"2025-08-08T11:00:00","modified_gmt":"2025-08-08T11:00:00","slug":"methotrexate","status":"publish","type":"product","link":"https:\/\/filarabiomed.ro\/en\/product\/methotrexate\/","title":{"rendered":"Methotrexate"},"content":{"rendered":"

An antineoplastic agent that acts as an anti-metabolite of folic acid. Within the cell folic acid is reduced to dihydrofolic and tetrahydrofolic acid. Methotrexate competitively inhibits the enzyme dihydrofolate reductase and prevents the formation of tetrahydrofolate, which is necessary for purine and pyrimidine synthesis and consequently the formation of DNA and RNA. Most active against cells in the S phase.<\/p>\n

\u00a0<\/p>\n

Technical info<\/span><\/h3>\n

Storage condition<\/h4>\n
    \n
  • Store dry at room temperature<\/li>\n
  • Soluble in alkaline solutions<\/li>\n
  • Protect from light<\/li>\n<\/ul>\n

    Hazard statements<\/h4>\n
      \n
    • H301<\/span>\u00a0Toxic if swallowed<\/li>\n
    • H315<\/span>\u00a0Causes skin irritation<\/li>\n
    • H319<\/span>\u00a0Causes serious eye irritation<\/li>\n
    • H340<\/span>\u00a0May cause genetic defects<\/li>\n
    • H351<\/span>\u00a0Suspected of causing cancer<\/li>\n
    • H360<\/span>\u00a0May damage fertility or the unborn child<\/li>\n<\/ul>\n

      Precautionary statements<\/h4>\n
        \n
      • P201<\/span>\u00a0Obtain special instructions before use<\/li>\n
      • P280<\/span>\u00a0Wear protective gloves\/protective clothing\/eye protection\/face protection<\/li>\n
      • P308<\/span>\u00a0IF exposed or concerned:<\/li>\n
      • P313<\/span>\u00a0Get medical advice\/attention<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"

        CAS number 59-05-2
        \nMolecular weight C20<\/sub>H22<\/sub>N8<\/sub>O5<\/sub>\u00a0= 454.4<\/p>\n","protected":false},"featured_media":0,"template":"","meta":{"inline_featured_image":false},"product_brand":[190],"product_cat":[197],"product_tag":[],"class_list":["post-12179","product","type-product","status-publish","product_brand-duchefa","product_cat-antibiotics-selective-agents","first","instock","shipping-taxable","product-type-simple"],"yoast_head":"\nMethotrexate - Filara Biomed<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/filarabiomed.ro\/en\/product\/methotrexate\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Methotrexate - Filara Biomed\" \/>\n<meta property=\"og:description\" content=\"CAS number 59-05-2 Molecular weight C20H22N8O5\u00a0= 454.4\" \/>\n<meta property=\"og:url\" content=\"https:\/\/filarabiomed.ro\/en\/product\/methotrexate\/\" \/>\n<meta property=\"og:site_name\" content=\"Filara Biomed\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/filarabiomed.ro\/en\/product\/methotrexate\/\",\"url\":\"https:\/\/filarabiomed.ro\/en\/product\/methotrexate\/\",\"name\":\"Methotrexate - 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