{"id":12172,"date":"2025-08-08T11:00:00","date_gmt":"2025-08-08T11:00:00","guid":{"rendered":"https:\/\/filarabiomed.ro\/?post_type=product&p=12172"},"modified":"2025-08-08T11:00:00","modified_gmt":"2025-08-08T11:00:00","slug":"g-418-disulphate","status":"publish","type":"product","link":"https:\/\/filarabiomed.ro\/en\/product\/g-418-disulphate\/","title":{"rendered":"G-418 disulphate"},"content":{"rendered":"

G-418 is an aminoglycoside antibioticum and is applied as a selective agent in transformation experiments. The antibioticum binds to the 30S subunit of the prokaryotic ribosome, thereby inhibiting protein synthesis as well as generating errors in the transcription of the genetic code. Ribosomes of mitochondria and chloroplasts of higher plants are related to bacterial ribosomes and are also susceptible to aminoglycosides. Being a derivative of gentamycin, the antibioticum contains a additional 3\u2019OH that can be phosphorylated by NPT II. As a result of this phosporylation, the charge and the steriometric conformation of the G-418 molecule changes in such a way that the antibioticum is no longer capable of binding to the specific ribosome binding sites.G-418 is used as an alternative for kanamycin in monocots, e.g., rice, Lolium, Graminea which are highly resistant to the latter. In all cases G-418 was shown to be more effective. This is most probably due to the better binding characteristics of the gentamycine shaped structure of G-418.<\/p>\n

\u00a0<\/p>\n

Technical info<\/span><\/h3>\n

Storage condition<\/h4>\n
    \n
  • Store at 2-8 \u00b0C<\/li>\n
  • Soluble in water<\/li>\n<\/ul>\n

    Hazard statements<\/h4>\n
      \n
    • H312<\/span>\u00a0Harmful in contact with skin<\/li>\n
    • H332<\/span>\u00a0Harmful if inhaled<\/li>\n
    • H360<\/span>\u00a0May damage fertility or the unborn child<\/li>\n<\/ul>\n

      Precautionary statements<\/h4>\n
        \n
      • P280<\/span>\u00a0Wear protective gloves\/protective clothing\/eye protection\/face protection<\/li>\n
      • P302<\/span>\u00a0IF ON SKIN:<\/li>\n
      • P304<\/span>\u00a0IF INHALED:<\/li>\n
      • P308<\/span>\u00a0IF exposed or concerned:<\/li>\n
      • P313<\/span>\u00a0Get medical advice\/attention<\/li>\n
      • P341<\/span>\u00a0If breathing is difficult<\/li>\n
      • P352<\/span>\u00a0Wash with soap and water<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"

        CAS number 108321-42-2
        \nMolecular weight C20<\/sub>H40<\/sub>N4<\/sub>O10<\/sub>.2H2<\/sub>SO4<\/sub>\u00a0= 692.7
        \nAssay :> 650 microg \/ mg<\/p>\n","protected":false},"featured_media":0,"template":"","meta":{"inline_featured_image":false},"product_brand":[190],"product_cat":[197],"product_tag":[],"class_list":["post-12172","product","type-product","status-publish","product_brand-duchefa","product_cat-antibiotics-selective-agents","first","instock","shipping-taxable","product-type-simple"],"yoast_head":"\nG-418 disulphate - Filara Biomed<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/filarabiomed.ro\/en\/product\/g-418-disulphate\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"G-418 disulphate - Filara Biomed\" \/>\n<meta property=\"og:description\" content=\"CAS number 108321-42-2 Molecular weight C20H40N4O10.2H2SO4\u00a0= 692.7 Assay :> 650 microg \/ mg\" \/>\n<meta property=\"og:url\" content=\"https:\/\/filarabiomed.ro\/en\/product\/g-418-disulphate\/\" \/>\n<meta property=\"og:site_name\" content=\"Filara Biomed\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/filarabiomed.ro\/en\/product\/g-418-disulphate\/\",\"url\":\"https:\/\/filarabiomed.ro\/en\/product\/g-418-disulphate\/\",\"name\":\"G-418 disulphate - Filara Biomed\",\"isPartOf\":{\"@id\":\"https:\/\/filarabiomed.ro\/en\/#website\"},\"datePublished\":\"2025-08-08T11:00:00+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/filarabiomed.ro\/en\/product\/g-418-disulphate\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/filarabiomed.ro\/en\/product\/g-418-disulphate\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/filarabiomed.ro\/en\/product\/g-418-disulphate\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/filarabiomed.ro\/en\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Shop\",\"item\":\"https:\/\/filarabiomed.ro\/shop\/\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"G-418 disulphate\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/filarabiomed.ro\/en\/#website\",\"url\":\"https:\/\/filarabiomed.ro\/en\/\",\"name\":\"Filara Biomed\",\"description\":\"\",\"publisher\":{\"@id\":\"https:\/\/filarabiomed.ro\/en\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/filarabiomed.ro\/en\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/filarabiomed.ro\/en\/#organization\",\"name\":\"Filara Biomed\",\"url\":\"https:\/\/filarabiomed.ro\/en\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/filarabiomed.ro\/en\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/filarabiomed.ro\/wp-content\/uploads\/2024\/11\/logo-filara.png\",\"contentUrl\":\"https:\/\/filarabiomed.ro\/wp-content\/uploads\/2024\/11\/logo-filara.png\",\"width\":491,\"height\":170,\"caption\":\"Filara Biomed\"},\"image\":{\"@id\":\"https:\/\/filarabiomed.ro\/en\/#\/schema\/logo\/image\/\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"G-418 disulphate - Filara Biomed","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/filarabiomed.ro\/en\/product\/g-418-disulphate\/","og_locale":"en_US","og_type":"article","og_title":"G-418 disulphate - Filara Biomed","og_description":"CAS number 108321-42-2 Molecular weight C20H40N4O10.2H2SO4\u00a0= 692.7 Assay :> 650 microg \/ mg","og_url":"https:\/\/filarabiomed.ro\/en\/product\/g-418-disulphate\/","og_site_name":"Filara Biomed","twitter_card":"summary_large_image","twitter_misc":{"Est. reading time":"2 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/filarabiomed.ro\/en\/product\/g-418-disulphate\/","url":"https:\/\/filarabiomed.ro\/en\/product\/g-418-disulphate\/","name":"G-418 disulphate - Filara Biomed","isPartOf":{"@id":"https:\/\/filarabiomed.ro\/en\/#website"},"datePublished":"2025-08-08T11:00:00+00:00","breadcrumb":{"@id":"https:\/\/filarabiomed.ro\/en\/product\/g-418-disulphate\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/filarabiomed.ro\/en\/product\/g-418-disulphate\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/filarabiomed.ro\/en\/product\/g-418-disulphate\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/filarabiomed.ro\/en\/"},{"@type":"ListItem","position":2,"name":"Shop","item":"https:\/\/filarabiomed.ro\/shop\/"},{"@type":"ListItem","position":3,"name":"G-418 disulphate"}]},{"@type":"WebSite","@id":"https:\/\/filarabiomed.ro\/en\/#website","url":"https:\/\/filarabiomed.ro\/en\/","name":"Filara Biomed","description":"","publisher":{"@id":"https:\/\/filarabiomed.ro\/en\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/filarabiomed.ro\/en\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/filarabiomed.ro\/en\/#organization","name":"Filara Biomed","url":"https:\/\/filarabiomed.ro\/en\/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/filarabiomed.ro\/en\/#\/schema\/logo\/image\/","url":"https:\/\/filarabiomed.ro\/wp-content\/uploads\/2024\/11\/logo-filara.png","contentUrl":"https:\/\/filarabiomed.ro\/wp-content\/uploads\/2024\/11\/logo-filara.png","width":491,"height":170,"caption":"Filara Biomed"},"image":{"@id":"https:\/\/filarabiomed.ro\/en\/#\/schema\/logo\/image\/"}}]}},"_links":{"self":[{"href":"https:\/\/filarabiomed.ro\/en\/wp-json\/wp\/v2\/product\/12172","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/filarabiomed.ro\/en\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/filarabiomed.ro\/en\/wp-json\/wp\/v2\/types\/product"}],"wp:attachment":[{"href":"https:\/\/filarabiomed.ro\/en\/wp-json\/wp\/v2\/media?parent=12172"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/filarabiomed.ro\/en\/wp-json\/wp\/v2\/product_brand?post=12172"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/filarabiomed.ro\/en\/wp-json\/wp\/v2\/product_cat?post=12172"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/filarabiomed.ro\/en\/wp-json\/wp\/v2\/product_tag?post=12172"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}